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Characterizing the pharmacokinetics of buccal absorption of resveratrol and it’s effects on NAD+ levels in human plasma.

Resveratrol, a natural phenol found in some plants, has been shown in many animal models to decrease blood sugar, provide some cardio-protection, and even have beneficial effects on lifespan. However, few human studies have been conducted and of the little research available, the results did not mimic those found in the animal models. 

Resveratrol has been shown by ARI researchers in both in vitro and in vivo studies, to manipulate NAD+, a molecule that is heavily involved in cellular respiration, metabolism, and repair of oxidative damage. By studying the pharmacokinetic characteristics of resveratrol we will identify whether there is a relationship between resveratrol and an increase in NAD within the sample. This may provide a mechanism for manipulating the ageing process in humans.